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血尿酸水平与冠心病及其严重程度的相关性

刘颖颖,王林,马金萍,刘黎洁,孟冬梅   

  1. 天津医科大学第二医院
  • 收稿日期:2011-06-20 修回日期:2011-10-11 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 刘颖颖

Relationship of Serum Uric Acid Level With the Presence and Severity of Angiographic Coronary Artery Disease

  • Received:2011-06-20 Revised:2011-10-11 Published:2012-02-15 Online:2012-02-15

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摘要： 目的：研究血尿酸（UA）水平与冠心病（CAD）的发生及严重程度的相关性。方法：对251例接受冠脉造影的患者测定各项临床指标，根据冠脉造影结果分为CAD组和非CAD组，以发生病变的血管支数反映冠心病严重程度。结果：（1）总体CAD组血尿酸水平高于非CAD组（p＜0.001），经Logistic 多因素回归分析显示尿酸水平为冠心病的危险因素(OR=1.007, 95%CI:1.002-1.011, p=0.004)。（2）冠状动脉病变1 支、2 支、3 支组尿酸水平均高于冠脉正常组（p＜0.05），但1支、2支、3支组间尿酸水平差异无统计学意义，按性别分组后，女性患者存在此相关性，但男性患者未得出。（3）血尿酸水平第3、第4四分位的CAD患病率明显高于第1、第2四分位(p＜0.05）。结论：血清尿酸水平与冠心病的发病率有关，但与冠状动脉病变程度无明显相关性。血尿酸水平在冠心病诊断中有一定价值。

关键词: 冠心病, 血尿酸, 冠脉造影, 危险因素

Abstract: Objective： The study was designed to determine the relationship between serum uric acid (UA) level and the presence and severity of coronary artery disease (CAD). Methods: A Total of 251 patients who underwent coronary angiography were included in this study according to the inclusion criteria. Patients were divided into CAD group and Non-CAD group according to the results of angiography. The severity of CAD was measured in terms of the number of vessels with disease. Results：1. The serum uric acid level was higher in CAD patients than that of Non-CAD patients (p＜0.001). Logistic regression analysis showed that the serum uric acid level was an independent risk factor of CAD (OR=1.007, 95%CI:1.002-1.011, p=0.004). 2. Although the serum uric acid level of one-, two-, three-vessel disease was higher than the non- vessel disease（p＜0.05）, among the three group there was no significant association. The same results were found in women, there was no significantly different. in men. 3. A significantly higher percentage of CAD patients was found in UA levels in the range of quartile 3 and 4 than that of UA levels of quartile 1 and 2 (p＜0.05). Conclusion: In conclusion, UA level was found to be associated with the presence but not with the severity of CAD. Particular attention should be paid with the UA level in clinical CAD diagnosis.

Key words: coronary artery disease, serum uric acid, coronary angiography, risk factors