天津医药

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中老年单纯收缩期正常高值血压与冠心病的关系

陈孟英1,张晶2,王伟3,梁蓉2   

  1. 1. 天津市胸科医院心内科
    2. 天津市胸科医院
    3. 天津市胸科医院 心内六科
  • 收稿日期:2012-12-18 修回日期:2013-03-19 出版日期:2013-08-15 发布日期:2013-08-15
  • 通讯作者: 陈孟英

Relation of Isolated Systolic High-Normal Blood Pressure and Coronary Heart Disease in Middle-Aged and Elderly Persons

CHEN Mengying ,ZHANGJing ,WANGWei ,liangrong liang rong   

  1. Department of Cardiology, Tianjin Chest Hospital, Tianjin 300051, China
  • Received:2012-12-18 Revised:2013-03-19 Published:2013-08-15 Online:2013-08-15
  • Contact: CHEN Mengying

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摘要： 【摘要】 目的 探讨中老年单纯收缩期正常高值血压患者发生冠心病的风险。 方法 选择 236 例接受冠状动脉造影检查的血压正常高值的中老年患者， 按照血压水平分为单纯收缩期正常高值血压（ISHNBP）组 135 例和非单纯收缩期正常高值血压（NISHNBP）组 101 例， 收集患者的临床和冠状动脉造影资料。 结果 NISHNBP组和 ISHNBP组收缩压比较差异无统计学意义(P＞ 0.05)， ISHNBP舒张压较低并且脉压较大， 差异均有统计学意义(P＜ 0.01)。 多因素 Logistic 回归分析显示， 单纯收缩期正常高值血压是冠心病的独立危险因素(OR=2.67， 95%CI： 1.50~4.75， P＜0.01)。 单纯收缩期正常高值血压组冠状动脉病变血管分布更广泛(P＜ 0.01)。 结论 重视中老年单纯收缩期正常高值血压患者的冠心病风险并加以适当的干预， 可能有助于降低心脑血管疾病的发生率。

关键词: 高血压, 心肌收缩, 心舒期, 冠心病, 正常高值血压

Abstract: Abstract   Objective   To investigate the relationship between isolated systolic high-normal blood pressure and coronary heart disease (CHD) in a middle-aged and elderly population. Methods  Total of 236 patients over 50 years old and undergone coronary angiography were enrolled and divided into isolated systolic high-normal blood pressure (ISHNBP) group (n=135) and non-ISHNBP (NISHNBP) group (n=101) according to their systolic and diastolic blood pressure levels. All clinical and angiographic data were collected. Results   Compared to the NISHNBP group, systolic blood pressure in ISHNBP group was a bit lower but without statistical significance, while diastolic blood pressure was lower and the resulting pulse pressure was higher, both with statistical significance. Using multivariate Logistic for adjustment of age, gender and other common risk factors of CAS, isolated systolic high-normal blood pressure was associated with CHD (OR=2.67，95%CI:1.50~4.75, P<0.01). The distribution of diseased coronary vessel numbers was more extensive than in the ISHNBP group (P<0.01). Conclusion    In the middle-aged and elderly population studied, isolated systolic high-normal blood pressure is an independent risk factor of CHD.

Key words: hypertension, myocardial contraction, diastole, Coronary artery disease, high normal blood pressure