关键词: 肾透析, 动脉粥样硬化, 颈动脉, 超声检查, 多普勒, 彩色, 基质金属蛋白酶10, 金属蛋白酶1 组织抑制剂

Abstract: Objective   To explore whether there is an association between matrix metalloproteinase-10 (MMP-10) and atherosclerosis in maintenance hemodialysis patients. Method   All individuals were sampled randomly from our hospital, 60 patients from the center of blood purification, 30 healthy subjects from medical examination center whose carotid intima media thickness (cIMT) are normal. All indexes are taken to comparison between 2 groups. We analysis the association between MMP-10 and other indexes in experiment group, and divide these patients into 4 groups accord to MMP-10 and take the number of patients with increased cIMT and plague to comparison between 4 groups. Besides, we also take increased cIMT and plague into Logistic stepwise regression analysis. Results    1)There is significant difference of systolic pressure, diastolic pressure, Glu, Alb, BUN, Cr, HDLc, MMP-10, TIMP-1, cIMT between two groups. 2) There is positive association between serum MMP-10 and age, hsCRP, cIMT, PROCAM, but a negative association between serum MMP-10 and Alb (P＜0.05). We don’t find significant correlation between MMP-10 and TIMP-1. cIMT is positively and significantly associated with age, PROCAM, MMP-10(P＜0.05). We don’t find any significant correlation between TIMP-1 and other items. 3) The patients with increased cIMT (χ2=8.938，P=0.030) and plague (χ2=8.782，P=0.032) are increased with a higher concentration. 4) Logistic stepwise regression analysis reveals the increased LDL-c/HDL-c may be a risk factor of the increased cIMT in maintenance hemodialysis patients.Overweight and increased cIMT may be risk factors of the plague(P＜0.05) in maintenance hemodialysis patients. Conclusion    MMP-10 is positively and significantly associated with cIMT and plague, but MMP-10 is not the risk factor of them.

Key words: Renal dialysis, Atherosclerosis, Carotid artery, Ultrasonography, Doppler, color, 金属蛋白酶1 组织抑制剂