天津医药

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磺胺嘧啶银霜治疗中华眼镜蛇咬伤坏死的价值探讨

王威,李其斌   

  1. 广西医科大学第一附属医院
  • 收稿日期:2010-01-27 修回日期:2010-03-23 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 李其斌

Approach of swell and necrosis in local skin and parenchyma by Chinese cobra snakebite

  • Received:2010-01-27 Revised:2010-03-23 Published:2010-08-15 Online:2010-08-15

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摘要： 【摘要】 目的:探讨中华眼镜蛇咬伤致局部皮肤软组织肿胀坏死合理有效的治疗方法。方法:回顾性分析我院2003年6月至2009年6月间收治中华眼镜蛇咬伤中毒67例患者的临床资料，并将67例患者分为三组，其中磺胺嘧啶银霜组22例、40%硫酸镁甘油组26例以及季德胜蛇药片组19例，分别外敷治疗局部皮肤软组织肿胀坏死，以消肿时间和愈合时间为观察对象进行统计学分析。结果:磺胺嘧啶银霜组、40%硫酸镁甘油组与季德胜蛇药片组的平均消肿时间分别为（8.82±1.92）天、（10.35±2.10）天和（11.42±2.61）天，三组间差异有统计学意义(F=7.305, p <0.05)；组间两两比较发现磺胺嘧啶银霜组与40%硫酸镁甘油组、季德胜蛇药片组间差异均有统计学意义(p <0.05)，而40%硫酸镁甘油组与季德胜蛇药片组间差异无统计学意义(p ＞0.05)。磺胺嘧啶银霜组、40%硫酸镁甘油组与季德胜蛇药片组的平均愈合时间分别为（17.45±6.67）天、（19.92±7.63）天和（20.74±8.50）天，三组间差异无统计学意义(F=1.077, p ＞0.05)。结论: 磺胺嘧啶银霜治疗中华眼镜蛇咬伤所致的局部皮肤软组织肿胀坏死在消肿方面较40%硫酸镁甘油与季德胜蛇药片占优，而在愈合时间上三种方法无优劣。

关键词: 中华眼镜蛇, 肿胀, 坏死, 治疗探讨

Abstract: 【Abstract】 Objective To approach the effective therapy of the swell and necrosis in local skin and parenchyma by Chinese cobra snakebite. Methods The clinical data of 67 patients those all were bitten by Chinese cobra, were divided into three groups and were paved sulfadiazine silver,40%magnesium sulfate glycerol and jidesheng snake tablet respectively. Detumescence time and healing time were compared and analyzed. Results The mean detumescence time of group sulfadiazine silver,40%magnesium sulfate glycerol and jidesheng snake tablet were （8.82±1.92）days、（10.35±2.10）days and（11.42±2.61）days respectively, there were difference of statistical significance in the three groups (p<0.05).Compared by each two groups, there were both difference of statistical significance between the sulfadiazine silver group to the 40%magnesium sulfate glycerol group and the jidesheng snake tablet group (p<0.05),but there were no difference of statistical significance between the 40%magnesium sulfate glycerol group and the jidesheng snake tablet group (p>0.05).The mean healing time of group sulfadiazine silver,40%magnesium sulfate glycerol and jidesheng snake tablet were （17.45±6.67）days、（19.92±7.63）days and（20.74±8.50）days respectively. There were no difference of statistical significance in the three groups (p>0.05). Conclusions Treating the swell and necrosis in local skin and parenchyma by Chinese cobra snakebite, the efficacy of sulfadiazine silver was better than the 40%magnesium sulfate glycerol and jidesheng snake tablet at detumescence time, but there were no good and bad at healing time.

Key words: Chinese cobra, Swell, Necrosis, Therapy approach