天津医药

• 论著 •    

T细胞非霍奇金淋巴瘤CCR7、MMP-9及VEGF表达意义初探

王晟怡1,赵国范2,杨晶1,白雪3,张云霄2,许秀丽2   

  1. 1. 天津医科大学
    2. 00
    3.
  • 收稿日期:2009-09-11 修回日期:2010-01-20 出版日期:2010-05-15 发布日期:2010-05-15
  • 通讯作者: 杨晶

Pilot Study of Expression of CCR7,MMP-9 and VEGF in T-cell Non-Hodgkin's lymphomas

  • Received:2009-09-11 Revised:2010-01-20 Published:2010-05-15 Online:2010-05-15

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摘要： 摘要　目的：研究C类趋化因子受体-7（chemokine C receptor 7，CCR7）、基质金属蛋白酶-9（matrix　metalloproteinase-9，MMP-9）及血管内皮生长因子（vascular endothelial growth factor，VEGF）在T细胞非霍奇金淋巴瘤（T-cell　non-Hodgkin’s　Lymphoma，T-NHL）中的表达及其临床意义。方法：收集41例T细胞非霍奇金淋巴瘤及19例反应性增生淋巴结标本及其临床病理资料，应用免疫组织化学染色检测CCR7、MMP-9及VEGF的表达，并分析其表达与临床病理指标之间的关系。结果：CCR7、MMP-9及VEGF在T细胞非霍奇金淋巴瘤中的高表达率分别为85.37%、90.24%及56.10%，均高于其在反应性增生淋巴结组织中的高表达率，差异均具有统计学意义（Pc=0.000，Pm=0.000，Pv=0.000）。多部位发生组CCR7、MMP-9的高表达率（92.86%，92.86%）高于单部位发生组（69.23%，84.62%），差异均具有统计学意义（Pc=0.001，Pm=0.041）；肿瘤大小＞3cm的患者MMP-9高表达率（96.00%）高于肿瘤大小≤3cm的患者（81.25%），差异具有统计学意义（P=0.024）。CCR7、MMP-9及VEGF之间未检测到协同表达。结论：T细胞非霍奇金淋巴瘤中存在CCR7、MMP-9及VEGF的高表达，这些蛋白的高表达对于提示预后较差具有一定的价值。

关键词: T细胞非霍奇金淋巴瘤, C类趋化因子受体-7, 基质金属蛋白酶-9, 血管内皮生长因子, 预后

Abstract: Pilot Study of Expression of CCR7,MMP-9 and VEGF in T-cell Non-Hodgkin’s Lymphomas WANG Sheng-Yi, ZHAO Guo-Fan, YANG Jing, BAI Xue, ZHANG Yun-Xiao, XU Xiu-Li Department of Pathology, Tianjin Medical University, Tianjin 300070, China ABSTRACT Objective: To investigate the expression and clinical significance of Chemokine C Receptor-7（CCR7）,Matrix Metalloproteinase-9(MMP-9) and Vascular Endothelial Growth Factor(VEGF)in T-cell non-Hodgkin’s Lymphomas(T-NHL).Methods: Specimens of 41 T-NHL cases and 19 reactive lymphoid hyperplasia cases were collected along with their clinicopathologic data. The expression of CCR7,MMP-9 and VEGF were detected using immunohistochemical staining and were then used to study the correlation between the expression and clinicopathologic factors. Results:The expression of CCR7,MMP-9 and VEGF were high in T-NHL group while low in the control group and the overexpression rates in T-NHL group were 85.37%,90.24%,56.10%, respectively.There was a significant difference in the overexpression rates of CCR7 and MMP-9 betwween the cases with more than one lesions and with single lesion, 92.86% vs 69.23% (Pc=0.001)，92.86% vs 84.62% （Pm=0.041），respectively. There was also a significant difference in the overexpression rates of MMP-9 between the groups classified according to their size(smaller or greater than 3cm),81.25% vs 96.00%(P=0.024).There was no correlation among the expression of CCR7, MMP-9 and VEGF.Conclusion: Overexpression of CCR7, MMP-9 and VEGF were detected in T-cell non-Hodgkin’s Lymphomas and the overexpression of these protein are unfavorable factors influencing prognosis of T-NHL patients.

Key words: T-NHL, CCR7, MMP-9, VEGF, prognosis