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前列腺导管腺癌一例报告

解春军   

  1. 天津市蓟县中医医院
  • 收稿日期:2011-01-17 修回日期:2011-05-12 出版日期:2011-09-15 发布日期:2011-09-15
  • 通讯作者: 解春军

Ductal Adenocarcinoma of the Prostate(a case report and literature review)

Xie Chun Jun ZHANG gang WU chang li   

  • Received:2011-01-17 Revised:2011-05-12 Published:2011-09-15 Online:2011-09-15
  • Contact: Xie Chun Jun ZHANG gang WU chang li

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摘要： 【摘要】 目的 探讨前列腺导管腺癌的临床特征及诊疗。方法 总结1例前列腺导管腺癌患者的临床。男性， 82岁，主因“尿频、尿急7年，加重3月”入院。血清总PSA为2.38 ng?ml-1，直肠指诊（DRE）未见异常，经直肠B超引导下前列腺穿刺病理活检提示：右中PIN 1级，其余部位前列腺增生伴炎症，实施经尿道前列腺电切术（TURP）。结果 病理报告：前列腺导管腺癌，Gleason分级5＼3（SUM =8分）。免疫组化染色PSA (+)，前列腺酸性磷酸酶(PAP)(+)，低分子角蛋白（CKAE）+，高分子角蛋白(CKHW) +，雄激素受体(AR)(-)。患者术后恢复良好，行雄激素阻断内分泌治疗。随访12个月，B超及直肠指诊（DRE）检查未见异常。结论 前列腺导管腺癌在前列腺癌中罕见，难于早期诊断，确诊主要依赖免疫组织化学检查，治疗上多采用TURP+激素和／或放疗为主。

关键词: 前列肿瘤, 导管腺癌, 诊断, 治疗

Abstract: 【Abstract 】 Objective To reported a case of Ductal Adenocarcinoma of the Prostate g and the relevant literature was reviewed to investigate the diagnosis and treatment of this disease．evaluate the clinical and pathological characteristics treatment ,prognosis of ductal adenocarcinoma of the Prostate．Methods A 82-year-old male suffered from "frequency, urgency, 7 years, increased for 3 months" misdiagnosis of patients. His serum prostatic specific antigen(PSA)level was 2.38 ng?ml-1．transurethral prostatic resection，(TURP) was performed on him．Results The postoperative pathology showed a primary Ductal Adenocarcinoma．Gleason score was 8．With immunohistochemical staining，the tumor cells were positive for PSA ,PAP (prostatic acid phosphatase) ,CKAE and CKHW，but negative for androgen receptor．Postoperatively，the patient recovered fairishly but long-term effects need further follow-up．Conclusion Ductal Adenocarcinoma of the Prostate is a clinically rare subtype of prostate cancer and difficult to be found in early stage．The diagnosis depends on histopathologic and immunohistochemical studies．Radical prostatectomy is recommended for this disease．

Key words: prostate cancer, ductal adenocarcinoma, diagnosis, treatment.