天津医药

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表皮生长因子甘草锌复合膜治疗口腔溃疡的动物实验研究

杨凤坤   

  1. 天津市口腔医院
  • 收稿日期:2009-11-04 修回日期:2010-01-28 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 杨凤坤

Animal Experimental Study of Oral Ulcer by Compound Epidermal Growth Factor And Glycyrrhizic Zinc Pellicles

  • Received:2009-11-04 Revised:2010-01-28 Published:2010-07-15 Online:2010-07-15

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摘要： 探讨表皮生长因子甘草锌复合膜对口腔溃疡动物模型的疗效。方法：将24只家兔随机分为治疗组、对照组和空白组，各8只。以冰醋酸润湿脱脂棉，在家兔右侧靠口角黏膜处烧灼1 min，生理盐水冲洗5min，24 h形成溃疡。溃疡形成后每日8点、12点、16点对家兔进行麻醉，治疗组使用复合膜治疗2 h，对照组使用本院制剂溃疡糊剂治疗2 h，空白组不作治疗，疗程为5 d，每日测量家兔溃疡面最大直径，进行组间对比观察。结果：（1）治疗至第3天时，治疗组疗效优于对照组及空白组（P＜0.05），对照组与空白组差异无统计学意义（P＞0.05）；治疗第5天时，治疗组及对照组疗效差异无统计学意义（P＞0.05），但均优于空白组（P＜0.05）。（2）在外观治愈的家兔中，对照组家兔组织上皮已修复，但比正常组织薄，固有层纤维比正常组织疏松；治疗组家兔上皮表面不全角化，与正常组织形态基本一致。结论：表皮生长因子甘草锌复合膜疗效确切，可对口腔溃疡动物模型进行有效治疗。

关键词: 复发性口腔溃疡, 表皮生长因子, 甘草锌, 复合膜, 动物模型

Abstract: Objective: To investigate the efficacy of oral ulcer animal model by compound epidermal growth factor and glycyrrhizic zinc pellicles. Methods: The 24 rabbits were randomly divided into treatment group, control group and blank control group, all 8,burning 1 min on the rabbits right mouth mucosa with wet acetic acid cotton.Physiological saline wash 5 min, ulcers were formated after 24h. Anesthetized rabbits At 8:00, 12:00, 16:00 every day, The treatment group using the compound pellicles treated 2h,the control group using ulcer paste treated 2h, the control group no treatment,treatment for 5d.Daily measurement of maximum diameter of ulcers in rabbits,comparison between groups observed. Results: When treatment to the 3rd day, the treatment group was more effective than the control group and blank group（P＜0.05）, there was no significant difference between the control group and blank group（P＞0.05）;when treatment to the 5th day,there was no significant difference between the control group and treatment group（P＞0.05）, but the two groups were all more effective than blank group（P＜0.05）.(2)Rabbits in the appearance of cure, organization of the control group of rabbits has been repaired epithelium, but thinner than normal tissue,lamina fiber was loose than normal tissue; epithelial surface incomplete keratinizated, was basically consistent with the normal tissue.Conclusions: The exact effect of compound epidermal growth factor and glycyrrhizic zinc pellicles can be effective for treatment of oral ulcer ainimal model.

Key words: recurrent oral ulcer, epidermal growth factor, glycyrrhizic zinc, compound pellicles, animal model