天津医药

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异丙酚对大鼠失血性休克复苏后肠道保护作用

常杰1,常文秀2,王勇强3,曹书华4   

  1. 1. 天津医科大学第一中心医院ICU
    2. 第一中心医院急研所
    3. 天津市第一中心医院急救研究所
    4. 天津市第一中心医院ICU
  • 收稿日期:2010-06-21 修回日期:2010-09-06 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 常杰

The protective effect on intestine of propofol after hemorrhagic shock and resuscitation

  • Received:2010-06-21 Revised:2010-09-06 Published:2011-04-15 Online:2011-04-15

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摘要： 摘 要：目的：通过测定肠道组织中SOD、MDA、血浆中DAO水平的变化探讨异丙酚对失血性休克复苏后肠道保护作用。方法：Wistar大鼠24只随机分为假手术组（C组）、失血性休克复苏组（THR-S组）、异丙酚组（P组）共3组，每组8只。建立失血性休克复苏动物模型，THR-S组在复苏后采用微量泵持续泵入生理盐水1ml/kg/h维持2小时，P组在复苏后采用微量泵持续泵入异丙酚1ml/kg/h维持2小时，到达时点后分别取材。结果：THR-S组及P组MDA及DAO水平均较C组升高（P<0.05），P组较THR-S组有所降低（P<0.05）；THR-S组及P组SOD水平较C组降低（P<0.05），P组较THR-S组有所升高（P<0.05）。结论：失血性休克复苏后肠道组织出现明显的损伤，异丙酚可通过抗氧自由基减轻此种损伤。

关键词: 异丙酚, 休克/复苏后, 肠道损伤, 保护

Abstract: Abstract：Objective: To determine the protective effect on intestine of propofol after hemorrhagic shock and resuscitation by measuring the changes of intestinal SOD and MDA and plasma DAO levels. Method: Thirty Wistar rats were randomized into 3 groups: sham operation group, resuscitation group and propofol group. There were 10 rats in each group. To establish animal models of hemorrhagic shock and resuscitation. Following resuscitation, the resuscitation group was infused normal saline at 1ml/kg/h with infusion pump for 2 hours, the propofol group was infused propofol at 1ml/kg/h for 2 hours. Then sampling in each group. Results: The MDA and DAO levels in the resuscitation group and the propofol group were higher than those in the sham operation group (P<0.5)，Propofol group was lower than resuscitation group(P<0.5) ; but SOD levels were lower than those in the sham operation group (P<0.5), Propofol group was higher than resuscitation group(P<0.5). Conclusion: The intestinal tissue was significantly damaged after hemorrhagic shock and resuscitation, propofol can reduce this damage by against the oxygen free radicals.

Key words: propofol, shock, intestine injury, protect