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eNOs基因T786C多态性与原发性高血压的关系

梁蓉   

  1. 天津市胸科医院
  • 收稿日期:2011-04-26 修回日期:2011-08-23 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 梁蓉

A study on the association of the polymorphism of endothelial nitric oxide synthase gene T786C with essential hypertension

liangrong liang rong   

  • Received:2011-04-26 Revised:2011-08-23 Published:2012-03-15 Online:2012-03-15
  • Contact: liangrong liang rong

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摘要： 目的 探讨eNOs基因T786C多态性与原发性高血压的相关性。方法 高血压患者266例，设对照组。取血标本提取DNA。采用多聚酶链式反应结合限制性内切酶片段长度多态分析方法检测eNOs基因T786C多态性。结果 (1) eNOs基因T786C各基因型（TT，TC，CC）在高血压组与对照组中的分布差异无显著性（P>0.05）;高血压患者中TC+CC基因型携带者的收缩压及舒张压均高于TT基因型携带者，但差异无显著性（P>0.05）。(2)T786C变异基因型在饮酒患者，男性患者中对收缩压具有正显著影响（P<0.05）。结论eNOs基因T786C多态性在我市高血压发病中不起直接重要作用，但可能通过影响相关危险因素参与高血压发病机制。

关键词: 原发性高血压, 基因多态性, 一氧化氮合酶

Abstract: Objective To investigate the association of the polymorphism of eNOs gene T786C with essential hypertension.Methods Two hundred and sixty-six patients with EH and matched controls were selected.Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of eNOs gene.Results (1) There was no significant difference noticed in genotype distribution for the eNOs gene T786C genotype between hypertensive groups and controls.SBP and DBP of patients with C allele of eNOs gene were higher than those of TT genotype,but the differences were not significant.(2)Positive effect of the T786C mutant genotypes on SBP was significant in the drinkers and men. Conclusion Although the polymorphism of eNOs gene T786C did not seem to play an important and direct role in the pathogenesis of EH it might have indirect effects through certain risk factors.

Key words: essential hypertension, Gene polymorphism, Nitric oxide synthase