天津医药

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子宫内膜异位症患者血清与腹腔液中 RANTES 水平及其临床意义

高桂芹,林琬君,李宝森   

  1. 天津市中心妇产科医院
  • 收稿日期:2012-09-27 修回日期:2012-11-29 出版日期:2013-07-15 发布日期:2013-07-15
  • 通讯作者: 高桂芹

The Evaluation and Significance of RANTES in Serum and Peritoneal Fluid in Patients with Endometriosis

GAO Guiqin ,LIN Wanjun ,LI Baosen   

  1. Department of Gynecology, Tianjin Central Hospital of Cynecology Obstetrics, Tianjin 300100, China
  • Received:2012-09-27 Revised:2012-11-29 Published:2013-07-15 Online:2013-07-15
  • Contact: GAO Guiqin

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摘要： 【摘要】 目的  探讨RANTES在子宫内膜异位症(EM)发生发展中的作用及临床意义。方法  采用ELISA方法检测50例EM患者(EM组)、32例卵巢良性肿瘤患者(疾病对照组)以及30例正常妇女(正常对照组)血清中RANTES水平,检测EM组与疾病对照组患者腹腔液中RANTES水平,结合EM患者临床分期等资料进行比较分析。结果   EM组患者血清中RANTES水平(108.73±60.69)ng/L明显高于疾病对照组(31.26±20.33)ng/L及正常对照组(29.77±11.58)ng/L(均P<0.05)。EM组腹腔液中RANTES水平(726.31±259.83)ng/L明显高于疾病对照组(116.19±81.64)ng/L(P<0.05)。EM患者血清以及腹腔液中RANTES水平与r-AFS分期均呈正相关(rs分别为0.501和0.562,均P<0.01);腹腔液中RANTES水平与痛经评分呈正相关(rs=0.527,P<0.01);血清中RANTES水平与腹腔液中RANTES水平呈正相关(rs=0.363,P=0.01);血清及腹腔液中RANTES水平分别与病变组织炎症反应程度呈正相关(rs分别为0.326和0.391,P<0.05或P<0.01)。结论  RANTES在EM发生发展中起重要作用,ELISA方法检测EM患者血清中RANTES水平可以作为EM诊断的辅助指标。

关键词: 子宫内膜异位症, 趋化因子类, 趋化因子CCL5, 血清, 炎症, 免疫, 痛经, RANTES

Abstract: Abstract   Objective    To investigate the role and clinical significance of RANTES in endometriosis. Methods   The level of RANTES was examined by ELISA in serum of 50 patients with endometriosis(EM group), 32 patients with benign ovarian neoplasms (disease control group) and 30 normal control women (normal control group), and the level of RANTES was examined in peritoneal fluid in EM group and disease control group. Results   The level of RANTES in serum (108.73±60.69 ng/L) was more significantly increased in EM group than disease group(31.26±20.33 ng/L) and normal group(29.77±11.58 ng/L)( P<0.05).The level of RANTES in peritoneal fluid (726.31±259.83 ng/L )was more significantly increased than disease group(116.19±81.64 ng/L)( P<0.05). The level of RANTES in serum in EM group was positively correlated with clinical stage (rs=0.501，P<0.01). The level of RANTES in peritoneal fluid in EM group was positively correlated with clinical stage (rs=0.562，P<0.01). The level of RANTES in peritoneal fluid in EM group was positively correlated with dysmenorrhea score(rs=0.527，P<0.01). The level of RANTES in EM group in serum was positively correlated in peritoneal fluid (rs=0.363，P<0.05). The level of RANTES in serum and peritoneal fluid in EM group was positively correlated with inflammatory response degree respectively in endometriosic tissues(rs=0.326，P<0.05; rs=0.391，P<0.01). Conclusion  RANTES plays an important role in endometriosis. The level of RANTES in serum in endometriosis patients is helpful to evaluate the disease degree and may be one of parameters for understanding the endometriosis.RANTES may be as an inflammatory response marker.

Key words: Endometriosis, chemotactic factors, chemokine CCL5, Serum, inflammation, immunity, Dysmenorrhea, RANTES