天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (12): 1424-1427.doi: 10.11958/j.issn.0253-9896.2015.12.021

• 临床研究 • 上一篇    下一篇

RBP4 和omentin-1 与颈动脉狭窄缺血性脑卒中的关系

刘媛1，韩艳庆2△，李倩1，赵玉1，王义义1，陆连第1   

  1. 1 天津市海河医院脑系科（邮编300350）；2 天津市环湖医院十三病区
  • 收稿日期:2015-03-30 修回日期:2015-07-27 出版日期:2015-12-15 发布日期:2015-12-11
  • 通讯作者: △通讯作者E-mail：hanyanqing99@163.com E-mail:liuyanqing81@163.com
  • 作者简介:刘媛（1981），女，主治医师，硕士，主要从事脑血管病、痴呆方面研究

Correlation of RBP4 and omentin-1with ischemic stroke and carotid artery stenosis

LIU Yuan1, HAN Yanqing2△, LI Qian1, ZHAO Yu1, WANG Yiyi1, LU Liandi1   

  1. 1 Department of Brain, Tianjin Haihe Hospital, Tianjin 300350, China；2 Thirteenth Ward, Tianjin Huanhu Hospital
  • Received:2015-03-30 Revised:2015-07-27 Published:2015-12-15 Online:2015-12-11
  • Contact: △Corresponding Author E-mail: hanyanqing99@163.com E-mail:liuyanqing81@163.com

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摘要： 目的探讨血清中视黄醇结合蛋白4（RBP4）和网膜素-1（omentin-1）与颈动脉狭窄缺血性脑卒中的关系。方法选取50 例对照人群，143 例颈动脉狭窄缺血性脑卒中患者。缺血性脑卒中患者根据超声多普勒分为轻度狭窄组（颈动脉正常或狭窄＜50%，67 例）、中度狭窄组（颈动脉狭窄50%～70%，45 例）和重度狭窄组（颈动脉狭窄>70%至接近闭塞，31 例）。自动生化分析仪检测各组体质指数（BMI）、高血压情况、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和空腹血糖（FPG），用ELISA 法检测各组血清中RBP4 和omentin-1 的含量，分析颈动脉狭窄缺血性脑卒中的危险因素。结果中、重度颈动脉狭窄组合并高血压比例明显多于对照组及轻度狭窄组（P＜0.05），血清TC、TG、LDL-C、FPG 和RBP4 水平明显高于对照组（P＜ 0.05），而omentin-1 水平明显低于对照组（P＜0.05）。Logistic 回归显示高TC、RBP4 是颈动脉狭窄缺血性脑卒中的危险因素，而高omentin-1 是保护因素。结论脂肪因子RBP4 是发生颈动脉狭窄缺血性脑卒中的危险因素而 omentin-1 是保护因素。

关键词: 颈动脉狭窄, 脑缺血, 卒中, 视黄醇结合蛋白质类, 网膜素-1, 视黄醇结合蛋白4

Abstract: Objective To investigate the correlation of serum levels of retinol binding protein 4 (RBP4) and andomen⁃ tin-1 with ischemic stroke and carotid artery stenosis. Methods Healthy adult (n=50) were selected as the control group while ischemic stroke patients with different degrees of carotid artery stenosis (n=143) were enrolled as the disease group. According to the ultrasonic Doppler performance, these ischemic stroke patients were divided into three groups: mild steno⁃ sis group (carotid artery stenosis was normal or less than 50%, n=67), moderate stenosis group (carotid artery stenosis was 50% to 70%, n=45), severe stenosis group (carotid artery stenosis was 70% to total occlusion, n=31). BMI index, hyperten⁃ sion, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and fasting blood glucose (FPG) were detected by Automatic biochemical analyzer and serum levels of RBP4 and omentin-1 were measured by ELISA. Results Hypertensive population in carotid artery stenosis group was larger than that in control group (P＜0.05). Serum TC, TG, LDL, FPG and RBP4 levels were significantly higher while omentin-1 level decreased remarkably in disease group than those in the control group (P＜0.05). Logistic regression analysis showed that TC and RBP4 were the risk factors of ischemic stroke with carotid artery stenosis, while omentin-1 was a protective factor. Conclusion RBP4 is a risk factor for ischemic stroke with carotid artery stenosis and omentin-1 is a protective factor.

Key words: carotid stenosis, brain ischemia, stroke, retinol-binding proteins, omentin-1, retinol binding protein 4