天津医药 ›› 2016, Vol. 44 ›› Issue (5): 540-542.doi: 10.11958/20150110

• 专题研究-消化疾病 • 上一篇    下一篇

大肠癌组织癌细胞中 P-选择素的表达及其临床病理意义

罗春英 1, 黄炳臣 1, 黄琴 2, 陈家兴 2, 陆海善 1, 韦叶生 3, 王俊利 3, 黄照权 1△   

  1. 1广西百色, 右江民族医学院附属医院病理科(邮编 533000); 2右江民族医学院 2011级临床医学本科; 3右江民族医学院附属 医院检验科
  • 收稿日期:2015-08-18 修回日期:2015-10-20 出版日期:2016-05-15 发布日期:2016-05-18
  • 通讯作者: △通讯作者 E-mail:huangzhq2012@163.com E-mail:86942091@qq.com
  • 作者简介:罗春英 (1977), 女, 副教授, 硕士, 主要从事肿瘤临床病理研究
  • 基金资助:
    广西自然科学基金项目 (2011GXNSFA018194); 广西医学科学实验中心开放基金专项项目 (KFJJ2011-05); 自治区级大学生创 新创业训练计划立项项目 (201410599017)

Expression and clinical significance of P-selectin in colorectal cancer cells

LUO Chunying1, HUANG Bingchen1, HUANG Qin2, CHEN Jiaxing2, LU Haishan1, WEI Yesheng3, WANG Junli3, HUANG Zhaoquan1△   

  1. 1 Department of Pathology, The Affiliated Hospital of Youjiang Medical College for Nationalities, Guangxi 533000, China; 2 Clinical Medical Undergraduate Course Grade 2011, Youjiang Medical College for Nationalitie; 3 Department of Clinical Laboratory, The Affiliated Hospital of Youjiang Medical College for Nationalities
  • Received:2015-08-18 Revised:2015-10-20 Published:2016-05-15 Online:2016-05-18
  • Contact: △Corresponding Author E-mail:huangzhq2012@163.com E-mail:86942091@qq.com

摘要: 摘要: 目的 探讨 P-选择素蛋白在大肠癌组织癌细胞中的表达及其临床病理意义。方法 运用免疫组织化学 法, 采用 P-选择素抗体检测 116 例大肠癌组织和 57 例癌旁正常组织 P-选择素的表达情况, 比较和分析 P-选择素 在大肠癌组织癌细胞和正常肠黏膜组织中的表达差异及其临床病理意义。结果 P-选择素在大肠癌组织中的癌细 胞、 血管内皮细胞均有表达。肿瘤细胞 P-选择素阳性表达率(77.6%, 90/116)明显高于癌旁正常肠黏膜组织中腺上 皮细胞 P-选择素的阳性表达率(17.5%, 10/57), 差异有统计学意义(χ2=56.49, P<0.05)。然而, 肿瘤细胞 P-选择素 阳性表达率在不同肿瘤直径、 分化程度、 浸润深度和有无淋巴结转移患者间比较差异无统计学意义(80.6% vs. 74.1%、 79.0% vs. 74.3%、 78.4% vs. 76.9%、 82.7% vs. 73.4%, 均 P>0.05)。结论 大肠癌肿瘤组织中癌细胞表达 P-选 择素是该肿瘤的重要特征

关键词: 结直肠肿瘤, P 选择素, 免疫组织化学, 大肠癌

Abstract: Abstract:Objective To investigate the expression and clinical significance of P-selectin in colorectal cancer cells. Methods The protein expression of P-selectin was detected by immunohistochemistry in colorectal cancer tissues (n=116) and corresponding non- tumor normal mucosa(n=57). The differences of P- selectin expression in colorectal cancer tissues, corre⁃ sponding non-tumor normal mucosa and the clinical pathological significance were compared and analysed in two groups. Results The expression of P-selectin protein was found not only in vascular endothelial cells but also in colorectal cancer cells. The positive rate of P-selectin expression was apparently higher in colorectal cancer cells (77.6%, 90/116) than that in normal mucosa (17.5%, 10/57, χ2=56.49, P <0.05). However, there were no significance in positive rates of P-selectin in colorectal cancer cells between tumors with different diameters, different degrees of differentiation, different depths of infiltration and with or without lymph node metastasis (80.6% vs. 74.1%, 79.0% vs. 74.3%, 78.4% vs. 76.9%, 82.7% vs. 73.4%, P>0.05). Conclusion The high expression of P-seletin in colorectal cancer cells is an important characteristic of colorectal cancer.

Key words: colorectal neoplasms, P-selectin, immunohistochemistry, colorectal cancer