Abstract: Abstract: With the aging of the population, the incidence of osteoarthritis (OA) is increasing, and which often leads joint pain, limited movement, articular cartilage tissue inflammation and progressive degeneration. At present, the clinical ef⁃ fect of conventional therapy is not ideal, and it is often needed to be solved by surgery. In recent years, long chain noncoding RNA (lncRNA) has been found to be involved in a variety of mechanisms in the pathogenesis of OA, including inflammatory factors, mechanical factors and cell apoptosis. And specific micro RNA (miRNA) mediates the regulation of each process. Therefore, the study of target gene therapy for differentiated lncRNA is becoming more and more in-depth, hoping to find an effective method for human OA treatment.

Key words: osteoarthritis, gene expression regulation, inflammation, apoptosis, review, long noncoding RNA