Abstract: Objective To explore the clinical characteristics, drug types and mechanism of drug induced acute angleclosure glaucoma. Methods Clinical data of 10 patients (13 eyes) with drug induced glaucoma were collected in Tianjin Medical University Eye Hospital from August 2016 to November 2017. The history of primary disease, medication history, clinical features, treatment and prognosis were recorded and analyzed. Results There were 3 males and 7 females in 10 patients, with the average age 61.1 years old (46-81 years old). There were three cases of binocular glaucoma and seven cases of monocular glaucoma. In 10 patients the involved systemic diseases included acute abdominal disease, organophosphate poisoning, postoperative general anesthesia, cerebral infarction, plastic surgery of tongue cancer, respiratory system diseases, trigeminal neuralgia and depression. Among them, 3 cases had glaucoma history, and they were treated with anti-glaucoma surgery or laser iridotomy. The drugs involved in acute angle-closure glaucoma including atropine, alprostadil, albuterol, isopropyl, bromide, carbamazepine, olanzapine, lorazepam, azolam and hydrochlorothiazide. Eight patients accepted the conservative treatment and two accepted glaucoma cataract surgeries. Four patients were relieved after conservative treatment and 1 patient was eventually blinded due to higher intraocular pressure. Two patients underwent surgical treatment, intraocular pressure control was stable, and vision function was restored. Three patients were lost to follow-up. Conclusion Acute angle-closure glaucoma can be induced by the medication treatment for the systemic diseases, which can lead to serious complications. The clinicians should inquire the medical history, and take measures to prevent the onset of glaucoma, in order to save the visual function.

Key words: glaucoma, angle-closure, drug-induced glaucoma