Abstract: Objective To investigate the relationship between high-sensitivity C-reactive protein to albumin (hs-CRP/
Alb) ratio and recurrence cerebral infarction (RCI). Methods A total of 69 RCI patients hospitalized in Taizhou hospital
affiliated to Wenzhou medical university from January 2018 to December 2018 were selected as case group, and 107 first
cerebral infarction (FCI) patients were selected as control group. The clinical data were recorded. The levels of blood routine examination, erythrocyte sedimentation rate (ESR), glycosylated hemoglobin A1c (HbA1c), hs-CRP, alanine transaminase (ALT), aspartate transaminase (AST), low density lipoprotein cholesterol (LDL-C), glucose (Glu), homocysteine (Hcy), Alb,
total bilirubin (TBil), direct bilirubin (DBil) and prealbumin (PA) were detected, and hs-CRP/Alb were calculated.
Independent risk factors of cerebral infarction recurrence were analyzed by logistic regression, and the value of hs-CRP to
albumin ratio in predicting cerebral infarction recurrence was evaluated by ROC curve. Results In the univariate analysis,
the prevalence of diabetes, average hospital stay, average hospitalization cost, HbA1c, hs-CRP, TBil, DBil and hs-CRP/Alb
ratio were significantly higher in the RCI group than those in the FCI group, while Alb and PA were lower than FCI group
(P＜0.05). There were no significant differences in gender, hypertension, WBC, Glu, ALT, AST and LDL-C between the two
groups (P＞0.05). Multivariate Logistic regression analysis showed that DM (OR=3.834, 95%CI: 1.176-12.503, P=0.026）
and hs-CRP/Alb ratio (OR=8.513, 95%CI: 1.139-63.638，P=0.037) were independent risk factors for RCI. The ROC curve
showed that the area under the curve of hs-CRP/Alb ratio predicting RCI was 0.635 (95%CI: 0.551-0.719, P=0.033). When
the cut off value was 0.07, the sensitivity and specificity were 59.4% and 61.7% respectively. Conclusion The hs-CRP/
Alb ratio is an independent risk factor for cerebral infarction recurrence, and the hs-CRP/Alb ratio at the time of admission
is helpful for predicting the recurrence of cerebral infarction.

Key words: brain infarction, recurrence, prognosis, risk factors, ROC curve, hs-CRP/Alb ratio