Abstract: Abstract: Objective　To explore the effect of pomelo peel oil on myocardial necroptosis in rats after cardiopulmonary resuscitation. Methods　According to the random number table method, 50 male SD rats were divided into the sham group (Sham group), model group (CA group), glycerol group (GLY group), low-dose pomelo oil group (Low-does group) and high-dose pomelo oil group (High-dose group), 10 rats in each group. The Sham group only performed surgery. The other 4 groups were all established rat cardiac arrest/cardiopulmonary resuscitation (CA/CPR) models. After resumption of spontaneous circulation (ROSC), drugs were injected intravenously into CA group (normal saline), GLY group (10% glycerol), Low-dose group (20 mg/kg pomelo peel oil) and High-dose group (40 mg/kg pomelo peel oil). The lactic acid level and myocardial tissue HE staining were used for evaluating myocardial injury. Immunohistochemistry and Western blot assay were adopted for detecting TNF-α and p-MLKL in each group at 24 hours after resuscitation. Results　HE staining found that myocardial fiber swelling and nuclear contraction were serious in CA and GLY groups, myocardial cell swelling and cell destruction degree were slightly reduced in Low-dose group, and myocardial injury was significantly reduced in High-dose group. The lactic acid level (1.50 mmol/L±0.11 mmol/L) was significantly higher in the CA group than that in the Sham group (0.91 mmol/L±0.10 mmol/L) (P＜0.05). The lactic acid levels were significantly lower in the Low-dose group and High-dose group (1.21 mmol/L±0.08 mmol/L and 1.07 mmol/L±0.09 mmol/L) than those in CA and GLY groups (P＜0.05). The lactic acid levels were significantly lower in High-dose group than those in Low-dose group (P＜0.05). Immunohistochemistry and Western blot assay showed that compared with the Sham group, the expression levels of TNF-α and p-MLKL were significantly increased in CA group and GLY group (P＜0.05). Compared with CA group, the expressions of TNF-α and p-MLKL decreased significantly in Low-dose group and High-dose group (P＜0.05). There was no statistically significant difference in all indicators between the CA group and the GLY group. Conclusion　Pomelo peel oil may reduce myocardial ischemia-reperfusion injury by inhibiting necroptosis.