Abstract: Abstract: Objective　To analyze the prognostic factors of Trousseau syndrome with acute cerebral infarction using the least absolute shrinkage and selection operator (LASSO) regression. Methods　A total of 49 Trousseau syndrome patients with acute cerebral infarction were selected in this study. Patients were divided into the good prognosis group (＜3 points, n=17) and the poor prognosis group (≥3 points, n=32) according to the modified Rankin Scale (mRS) score 90 days after discharge. The general clinical data, imaging data on admission, laboratory examination results and prognosis were compared between the two groups. LASSO regression was used to screen variables related to prognosis, and the model was constructed. The predictive value of the model was evaluated by receiver operating characteristic (ROC) curve and H-L goodness of fit test. Results　There were 39 cases of adenocarcinoma in pathological type in all of patients. Compared with the good prognosis group, there were higher National Institutes of Health Stroke Scale (NIHSS) score at admission, higher proportion of patients diagnosed with tumor less than 6 months after cerebral infarction, lower hemoglobin (Hb) level, and lower proportion of patients treated with monoclonal anticoagulation in the poor prognosis group (P＜0.05). LASSO regression analysis showed that Hb level and monoclonal anticoagulation therapy were positively correlated with prognosis, and NIHSS score at admission was inversely correlated with prognosis. The AUC of the LASSO regression model was 0.871 (95%CI: 0.766-0.976), sensitivity was 0.875 and the specificity was 0.706. H-L goodness of fit test P=0.978. Conclusion　In Trousseau syndrome patients with acute cerebral infarction, Hb level and monoclonal anticoagulation therapy were positively correlated with prognosis, and NIHSS score at admission was inversely correlated with prognosis.

Key words: brain infarction, prognosis, anticoagulants, hemoglobins, Trousseau syndrome, LASSO regression, NIHSS score