Correlation between macular retinal thickness and urinary protein in adult patients with nephrotic syndrome

doi:10.11958/20221421

Abstract

Abstract:

Objective To investigate the correlation between retinal thickness in macular area and urinary protein in adult patients with nephrotic syndrome. Methods A total of 112 inpatients admitted to the internal medicine department were selected and divided into the normal urine protein group (28 cases, 56 eyes), the mildly abnormal urine protein group (30 cases, 58 eyes), the moderately abnormal urine protein group (27 cases, 51 eyes) and the nephrotic syndrome group (27 cases, 53 eyes) according to results of urine protein detection. Optical coherence tomography (OCT) was used to measure the average retinal thickness of the nine divisions in the macula regions, including the central region (Center), temporal side of the inner ring (InT), superior the inner ring (InS), nasal side of the inner ring (InN), inferior the inner ring (InI), temporal side of the outer ring (OutT), superior the outer ring (OutS), inferior the outer ring (OutI) and nasal side of the outer ring (OutN). The correlation ratio E² was used to analyze the correlation between the mean retinal thickness of different macular regions and the grading of urinary protein in each group. Results The mean retinal thickness of Center, InT, InN and InI in the macular area was higher in the mildly abnormal urine protein group than that in the normal urine protein group. The mean retinal thickness of Center, InT, InS, InN, InI and OutN in the macular area was lower in the moderately abnormal urine protein group than that in the mildly abnormal urine protein group, and the mean retinal thickness of InT, InS, InN and InI in the macular area was higher in the nephrotic syndrome group than that in the moderately abnormal urinary protein group (All P<0.05). The mean retinal thickness of InT, InS, InN and InI in macular area was moderately correlated with the severity of urinary protein group (0.06≤E²<0.16), while the mean retinal thickness of Center and OutN in macular area was weakly correlated with the severity of urinary protein group (E²<0.06). Conclusion The mean retinal thickness of InT, InS, InN and InI in macular area may be biomarkers of early lesions of adult nephrotic syndrome.

Key words: nephrotic syndrome, tomography, optical coherence, urine protein, macular retinal thickness

CLC Number:

R771.3

Figures/Tables 4

References 21

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组别	n	男性/例（%）	眼别（右/左）/例	年龄/岁
A组	28	22（78.6）	28/28	67.36±6.00
B组	30	23（76.7）	30/28	67.90±8.30
C组	27	22（81.5）	27/24	68.15±8.07
D组	27	20（74.1）	27/26	65.93±7.09
χ²或F		0.458	0.099	0.489

组别	n	男性/例（%）	眼别（右/左）/例	年龄/岁
A组	28	22（78.6）	28/28	67.36±6.00
B组	30	23（76.7）	30/28	67.90±8.30
C组	27	22（81.5）	27/24	68.15±8.07
D组	27	20（74.1）	27/26	65.93±7.09
χ²或F		0.458	0.099	0.489

组别	n		Center			InT			InS
A组	56		223.02±17.05			280.09±17.09			292.93±16.34
B组	58		240.03±23.56^a			291.02±21.98^a			301.29±19.49
C组	51		227.00±30.21^b			275.53±31.49^b			285.04±23.33^b
D组	53		235.38±40.30^a			291.66±35.43^ac			298.75±30.71^c
F			4.047^＊			4.664^＊			5.276^＊
组别		InN			InI			OutT
A组		292.79±17.85			285.95±19.77			250.41±14.27
B组		304.24±18.73^a			298.57±22.20^a			252.47±19.71
C组		286.94±28.18^b			280.53±30.86^b			245.41±25.32
D组		300.09±28.12^c			293.91±33.98^c			250.11±33.81
F		5.775^＊			4.792^＊			0.811
组别		OutS		OutI			OutN
A组		261.95±15.65		276.95±16.16			255.84±13.46
B组		263.95±17.93		280.31±20.72			258.33±18.30
C组		256.90±19.82		271.51±22.52			245.29±19.36^ab
D组		263.19±29.54		279.79±28.52			251.15±33.58
F		1.169		1.722			3.555^＊

组别	n		Center			InT			InS
A组	56		223.02±17.05			280.09±17.09			292.93±16.34
B组	58		240.03±23.56^a			291.02±21.98^a			301.29±19.49
C组	51		227.00±30.21^b			275.53±31.49^b			285.04±23.33^b
D组	53		235.38±40.30^a			291.66±35.43^ac			298.75±30.71^c
F			4.047^＊			4.664^＊			5.276^＊
组别		InN			InI			OutT
A组		292.79±17.85			285.95±19.77			250.41±14.27
B组		304.24±18.73^a			298.57±22.20^a			252.47±19.71
C组		286.94±28.18^b			280.53±30.86^b			245.41±25.32
D组		300.09±28.12^c			293.91±33.98^c			250.11±33.81
F		5.775^＊			4.792^＊			0.811
组别		OutS		OutI			OutN
A组		261.95±15.65		276.95±16.16			255.84±13.46
B组		263.95±17.93		280.31±20.72			258.33±18.30
C组		256.90±19.82		271.51±22.52			245.29±19.36^ab
D组		263.19±29.54		279.79±28.52			251.15±33.58
F		1.169		1.722			3.555^＊

指标	Center× 分组	InT× 分组	InS× 分组	InN× 分组	InI× 分组	OutN× 分组
Eta	0.232	0.248	0.262	0.274	0.251	0.218
E²	0.054^＊	0.061^＊＊	0.069^＊＊	0.075^＊＊	0.063^＊＊	0.047^＊