Abstract:

[Abstract] Objective To investigate the association of nonalcoholic fatty liver disease with hypertriglyceridaemic wasit phenotype complicated with type 2 diabetes mellitus. Methods Base on whether plasma triglycerides concentra?tion ≥1.7 mmol/L or not, waist circumference ≥90 cm or not in men or ≥85 cm or not in women, patients with type 2 diabe? tes mellitus (n=804) were divided into four groups: normal waist circumference with normal triglycerides, normal waist cir? cumference with hypertriglyceridemia, abdominal obesity with normal triglycerides and hypertriglyceridemic-waist pheno? type (HTWC). The four groups’ clinical data were recorded. Body mass index (BMI), homeostasis model assessment insulin resistance (HOMA-IR) and nonalcoholic fatty liver disease fibrosis score (NAFLDFS) were calculated and the results were compared among four groups. Results BMI, waist circumference, systolic blood pressure, diastolic blood pressure, HOMAIR, alanine aminotransferase, aspartate aminotransferase , γ-glutamyltransferase, serum uric acid， NAFLDFS and the inci? dence of NAFLD were all higher in the HTWC group compared to non-HTWC group (P＜ 0.01). Logistic regression analysis revealed that besides BMI， γ-glutamyltransferase and serum uric acid， HTWC was also a risk factor for NAFLD in patients with type 2 diabetes mellitus（OR=1.986， 95%CI:1.006-3.921）. Conclusion HTWC is a risk factor for NAFLD in patients with type 2 diabetes mellitus. Screening and diagnosis of HTWC is helpful for reducing the occurrence of NAFLD and can slow its progress through controlling and interfering metabolic disturbance.

Key words: fatty liver, diabetes mellitus, type 2, nonalcoholic fatty liver disease, hypertriglyceridaemic-waist phenotype