Abstract: Objective: To observe the changes in heart morphology of Yiqihuoxue treatment in Rabbits with pulmonary heart disease . Methods: We had randomly divided 32 healthy Japanese white rabbits into 4 groups, Normal Group(NG), Model Group(MG)，Chinese Medicine Group(CMG) and Captopril Group(CG). Three groups of above mentioned, MG，CMG and CG ,had been given a single dose of Fecl3 induced the model of pulmonary heart disease . Then after that, we treated the 2 groups of them, CMG and CG, respectively 20 days. We had observed and recorded the data of the general conditions, and detected all above groups by echocardiography before & after modeling, and after treating. Results: After modeling, there emerged some value of statistical difference on the field of echocardiographic parameters, such as right ventricular diameter（RVD）, pulmonary artery diameter(PAD), the thickness of right ventricular anterior wall(RVAW), tricuspid valve (TV)and pulmonary artery(PV) blood flow velocity(P <0.05 or P <0.01). After treating，We found the weight and breathe of CMG had been improved better than the CG.. We also observed the right ventricular diameter (RVD) was significantly less in the CMG than the other groups(P <0.05). Conclusion: Yiqihuoxue treatment can be effectively alleviate the symptoms，reduce the right ventricular diameter (RVD) and lower pulmonary artery pressure.

Key words: Pulmonary heart disease, pulmonary hypertension, rabbit, echocardiography, right ventricular