Abstract: Abstract Objective: To evaluate effect on prevention maternal/neonatal infectious morbidity by short-term prophylactic antibiotics at cesarean section with pelvic inflammatory disease (PID). Methods: All patients with PID found during cesarean section were collected during December 2009 to February 2011. Part of Perinatal infection were surveyed and compared between short-term (<24 hours, n = 109) and long-term (>48 hours, n = 118) prophylaxis by cefazolin sole or combined with metronidazole at cord clamping. Results: Statistical significant difference had not been shown in incidence of surgical site infections (SSIs), endometritis, puerperal morbidity on pregnant women who accepted cesarean section and found PID whether antibiotics were admitted by short-term or long-term. More than 86% cost reduction was found in prophylactic antimicrobial use by short-term antibiotics prophylaxis (RMB15.80±10.32 to RMB115.87±49.76, P = 0.00). Conclusion: short-term (<24 hours) prophylaxis by cefazolin sole or combined with metronidazole at cord clamping was safe and saved strategy to prevent SSIs of cesarean delivery.

Key words: surgical site infection, cesarean sectionpelvic inflammatory disease antibiotic prophylaxisshort-term