Abstract: [Abstract]Objective：Survey the clinical curative effect of Sodium Ferulate on Diabetic Nephropathy。Methord：Eighty-two Diabetic Nephropathy patients，divided into Conventional Therapy Group and Sodium Ferulate Therapy Group randomly，determine Urine Albumn Excretory Rate(UAER)、Blood Urea Nitrogen(BUN)、Serum Creatinine(SCr)、 Free Blood Glucose(FBG) and Mean Artery Pressure (MAP)of all patients，and take the data of pretherapy and post-treatment by comparison。Result：Maintenance single therapeutic regimen for four weeks，in Sodium Ferulate Therapy Group，UAER、SCr、BUN、MAP are significantly cut down（P<0.05，P<0.01），compared with the prethrepy data。However，there is no significant diference between the pretherapy data and post-treatment data。 Conclude：Sodium Ferulate therapy on Diabetic Nephropathy，the value of UAER、BUR、SCr and MAP of patients decrease。Conceivable mechanism is that Sodium Ferulate could inhibit the secretion of endothelin，or degrade the process of binding of endothelin and its receptor。

Key words: Sodium Ferulate, Diabetic Nephropathy, Endothelin