Abstract: Objective To study the possible relationship between genetic polymorphisms of interferon and early response of interferon alpha Methods Clinical data from 145 patients in the original trial were analyzed. The SNP of INF-r gene intron at position1 +874 was determined by the restriction fragment length polymorphism analysis.all patients recieve interferon alpha treatment Results AA genetype account for 77.3% of early non-response patients, account for 42.4% of early part response patients, account for 43.1% of early complete response patients.AA genetype is associated with a lower early response rate compared with the other two genetypes. Conclusion There was association between IFN-r gene polymorphism and the early response of interferon alpha treatment in CHB patients. This study suggested the possibility that IFN-r gene polymorphism(intron 1 at position + 874) might be important in determining an individual’s efficacy of interferon alpha by higer expression or promting effect of host target cells

Key words: Interferon alpha, Gene polymorphism, Chronic Hepatitis B, early response