Abstract: Objective：To study the efficacy of anti-adhesion agent used in preventing tubal obstruction after acute Pelvic Inflammatory Disease(PID)．Methods：The cervical and vaginal secretions of the patients with acute PID were collected for bacteria culture and test. All the patients received broad spectrum antibiotics. The patients recovered from acute PID were randomly divided into two groups, study group（n=30）and control group(n=30). The patients in the study group were given hydrotubation with regular drug and sodium hyaluronate for two times after menstrual period. The patients in each group were followed up on tubal patency exam after 1 month. Results：(1) In the PID patients the major etiological agents were eolibacillus, staphylococcus epidermidis, mycoplasma huminis (MH) and chlamydia trachomatis (CT). The combined infection rate was 64.8%，and 54.9% patients were concurrent infected with bacterial vaginosis(BV). (2) The tubal patency rate of study group after 1 month of treatment with sodium hyaluronate was 83.3%，which was significantly higher than 53.3% before treatment(P<0.05). After 1 month the tubal patency rate of study group treated with sodium hyaluronate was 83.3% which was significantly higher than 53.3% in the control group with statistical difference(P<0.05). Conclusions：(1)The etiological agents of PID always were combined infection. (2) Anti-adhesion agent could be effective to prevent tubal obstruction after PID．

Key words: pelvic inflammatory disease, etiological agents, hydrotubation, sodium hyaluronate