Abstract: Objective: To evaluate the association between hyperuricemia (HUA) and the presence and severity of angiographic coronary artery disease (CAD). Methods: The study group consisted of 647 consecutive patients undergone coronary angiography. The anthropometric measurements including serum uric acid for every patient were conducted. According to the results of angiography, the patients with or CAD were divided into two groups. The severity of CAD was measured in terms of the number of vessels with disease and Gensini score. Results: (1) In women, the HUA percentage was significantly higher in CAD patients than in non-CAD patients (P<0.01). (2) HUA was significantly associated with the presence of CAD only in women (OR = 2.022，95%CI: 1.098~3.723，P =0.023). However, after adjusting for age, the association was no longer significant (OR = 1.513，95%CI: 0.778~2.931，P=0.221). HUA was not an independent risk factor of CAD in both genders. (3) For both genders, the relation between HUA and the distribution of diseased vessel numbers was not significant in the CAD patients (P=0.57；P=0.30). For women the Gensini score was significantly higher in HUA patients than in non-HUA patients（P=0.04, and the rank correlation was found to be significant in the total, HUA and non-HUA groups （r= 0.181，P = 0.004；r= 0.291，P = 0.049；r= 0.138，P = 0.046） . Conclusion: In women, HUA was associated with CAD with statistic significance, but was not an independent risk factor for CAD. Particular attention should be paid in aged woman HUA patients in clinical CAD diagnosis.

Key words: coronary artery disease, serium uric acid, hyperuricemia, coronary angiography, risk factor