Abstract: Abstract Objective：To investigate the clinical features and OGTT results of 40 hypokalemic periodic paralysis cases. Methods：The clinical manifestations in 40 patients and OGTT results of 33 patients were analyzed and summarized. Results：40 patients had no clear hypoPP family history and they concurrent hyperthyroidism in 22 cases, subclinical hypothyroidism in 1 case and other 17 cases did not associated with any endocrine diseases after completing laboratory examinations .In comparison with the control，the OGTT results of 33 hypoPPs show a higher insulin level and insulin resistance. The deposition of immunoglobin on the muscle cell membrane in 16 cases was significantly increased. Conclusion：HypoPP can occur alone，also can concurrent hyperthyroidism. Hyperthyroidism and HypoPP can occur in a patient at the same time or in different periods . HypoPPs with or without hyperthyroidism have a higher insulin level and insulin resistance. Abnormal glucose metabolism and hyperinsulinemia may be one of the factors for disease.

Key words: Hypokalemic periodic paralysis , Insulin resistance, Hyperinsulinemia