Abstract: 【Abstract】 Objective To evaluate the value of cortical sensory evoked potential (Co-SEP) and motor evoked potential(Co-MEP)combined with the electrocorticogram (ECoG) in epilepsy surgery with the epileptogenic focus in central area. Methods 30 cases of intractable epilepsy patients with the epileptogenic focus in centra area underwent the surgery ,The Co-SEP and Co-MEP were performed to detect the motor，sensory areas before the lesions remova1,and the ECoG were performed to ditect the epileptogenic focus,The brain lesions were removed in the case of eloquent areas preservation and we adopted Multipal Subpial Transection (MST) to treat secondary epilepsy Result According to Engel criteria, 30 patients were followed up for 3 to 12 months, 18 cases were in level Ⅰ;7 cases were in level Ⅱ, 3 cases were in level Ⅲ,2 cases were in level Ⅳ.All patients had no motor dysfunction.Conclusion Intraoperative Co-SEP and Co-MEP combined with ECoG is a reliable，precise and safe method to detect eloquent areas，which allows a maximum resection of lesions and protection of the normal function and treat the secondary epilepsy ,improve the quality of patient’s life.

Key words: somatosensory evoked potentials, motor evoked potentials, electrocorticogram, central area, secondary epilepsy