Abstract: Abstract Objective: To evaluate the correlation between macular morphology and functional in patients with acute central serous chorioretinopathy (CSC). Methods: Thirty-six patients (36 eyes) with acute CSC underwent OCT and mfERG examinations. Macular morphology and its correlation with macular function in patients with acute CSC were explored. Results: There was negative correlation between height, ranges of detachment in macular areas and the best visual acuity (BCVA) (r=-0.922, P=0.000; r=-0.896, P=0.000). But no correlation between macular volume and BCVA (r=0.014, P=0.935). There was significantly negative correlation between BCVA and mfERG P1 latencies of ring 1~3, N1 latency of ring 2(rs=-0.488, P=0.003; rs=-0.514, P=0.001; rs=-0.452, P=0.006; rs=-0.445, P=0.007). There was negative correlation between BCVA and mfERG N1 amplitude density of rings 1, 2(rs=-0.497, P=0.002; rs=-0.502, P=0.002). There was negative correlation between height of detachment in macular area and P1 latency of ring 1, N1 latency of ring 2(rs =0.486，P=0.003; rs=0.421, P=0.011). Conclusions: Combined mfERG and OCT can accurately detect the macular morphology and function in acute central serous chorioretinopathy. There was a close relationship between height of detachment in macular area and macular function.

Key words: central serous chorioretinopathy, multifocal electroretinography, optical coherence tomography