Abstract: Abstract objectives： We talk about the role of neoadjuvant chemotherapy in the treatment of subglottic carcinoma on clinical and pathological features , surgical resection rate, survival rate, lymph node metastasis rate, quality of life and the clinical progonosis. Methods：Clinical data of 104 patients of supraglottic laryngeal carcinoma were analyzed retrospectively from 1995.5 to 2005.12. According to the classification system of AJCC 2002，the case numbers of stage I，II，III and IV were 7，30，41 and 26. 63 patients with neoadjuvant chemotherapy, the case numbers of stage I，II，III and IV were 5，18，24 and 16. Fiber laryngoscope line and CT examination should be taken before and after chemotherapy, underwent surgery a weak later. Survival analysis was performed by Kaplan-Meier method．The factors were compared using the log-rank test．The influencing factors were screened by Cox proportional hazards model. Results:In patients with tumor, confirmed by laryngoscopy and CT,Intraoperative assessment and pathological, completely remission(CR)7.93% (5/63), partial remission(PR)44.44% (28/63),the total effective rate(CR+PR) 52.37%.Log-rank approach was applied to compare the survival time of the preoperative chemotherapy group and non-chemotherapy group, inductes that chemotherapy on long-term survival is significant (P = 0.03), Cox model analysis shows that: N stage, pTNM histopathologic grade and relapse is an independent risk factor affecting survival (P all <0.05). , Neoadjuvant chemotherapy is protective factors （P <0.05）. Conclusion: The prognosis of supraglottic cancer is related to T stage, N stage, pTNM pathological classification, preoperative chemotherapy and relapse etc. Preoperative chemotherapy can improve survival rate, improve the resection rate and the prognosis of patients.

Key words: laryngeal neoplasms, squamous cell carcinoma, neoadjuvant chemotherapy, prognostic factor