Abstract: Objectives：To study the role of Sivelestat in the hepatic injury in rats with severe acute pancreatitis. Methods：Fifty-four SD rats were randomly divided into three groups: Control group (group A), severe acute pancreatitis group (group B) and treatment group with Sivelestat (group C). Each group was divided into 3h, 6h and 12h subgroups (n=6 in each subgroup). SAP was induced by retrograde injection of 3.5% sodium taurocholate into biliopancreatic duct. The level of serum IL-6, NE and ALT were measured. The levels of SOD, MDA ,MPOin hepatic tissue bomogenate were measured. Part of hepatic and pancreatic tissue were changed by HE staining. Results: ①In the SAP group serum levels of IL-6, NE, AMY, ALT increased significantly(P<0.05)and the pancreas and liver showed obvious pathologic changes. ②In the SAP group, the level of liver tissue bomogenate MDA and MPO increased significantly, and SOD significantly reduced. ③The treatment with Sivelestat, the levels of IL-6, NE, ALT, MDA and MPO decreased significantly and that of SOD increased, the liver and pancreatic pathologic damages score improved. Conclusion: The treatment with Sivelestat, a elastase inhibitor, could markedly atteneuate hepatic injury in SAP by effectively enhance the oxygen free radical scavenging capacity and inhibit neutrophil elastase and inflammatory reaction.

Key words: severe acute pancreatitis (SAP), liver damage(LD), oxygen free radical(OFR), interleukin-6(IL-6), neutrophil elastase(NE), Sivelestat