Abstract: 【Abstract】　Objective Study the expression and the Significance of PRL-3 and Microvessel dencity which was marked with CD l05 in laryngeal Squamous Cell quamous Cell carcinoma and 25 normal tissues was investigated by carcinoma. Methods :Expression of PRL-3 and MVD in samples of 69 laryngeal Susingmmunohistoehemieal methods of SABC respectively. Results:The expression of PhosPhatas of regenerating liver-3( PRL-3 )and MVD has close correlation with clinic stage of laryngeal carcinoma and lymph-node metastasis in carcinoma (p<0.05). PRL-3 hasSignificant correlation with the degree of histological differentiation but Microvessel dencity has no correlation with the degree of histological differentiation; Significant correlation could be established among the expression of microvessel density and PRL-3 (P<0?05).Conclusions：PRL-3 may be involved in laryngeal squamous cell carcinoma angiogenesis and promoted laryngeal squamous cell carcinoma metastasis.MVD had a close correlation with clinic stage of laryngeal carcinoma and lymph-nodemetastasis, It may be a valuable index to evaluate the prognosis of patients with laryngeal squamous cell carcinoma,also, MVD can provide the basis for anti-vascular therapy

Key words: laryngeal Squamous carcinoma, PRL-3, CD105, MVD