Abstract: Objective：To determine the risk factor for development of early acute renal failure in patients with open-heart surgery.Methods：1660 ASAⅡ-Ⅳ patients in our hospital from October 2005 to January 2010 under open-heart surgery were divided into acute renal failure group (ARF group) and no acute renal failure group (NARF group).ARF group had 78 cases and NARF group had 1582 cases.We compared the possible risk factor between groups and then applied the logistic regression to identify the risk factor of ARF.Result：Logistic analysis indicated that serum β2-microglobin higher than normal value before operation, the cardiopulmanory bypass time and the low cardiac output syndrome after operation were closely correlated with development of early ARF after open-heart surgy.Conclusion： Serum β2-microglobin higher than normal value before operation, the cardiopulmanory bypass time and the low cardiac output syndrome after operation are the risk factors for early ARF after open-heart surgy.

Key words: Heart surgery, Acute renal failure, β2-microglobin, cardiopulmanory bypass, low cardiac output syndrome