Abstract: [Abstract] Objective：To analyze the clinical characteristics of the Subcutaneous hemorrhage caused by combined Low Molecular Heparin(LMH) and Intermittent Pneumatic Compression therapy used in patients of TKA. Clinical data: 80 cases of total knee arthroplasty (TKA) patients were distributed into 2 groups: the experimental group (EG), and the control group (CG). In CG, we inject 5000u LMH subcutaneously every night; while in EG, besides the same LMH injection, IPC was used as a combination. And perimeters of extremities were matured, as well as temperature and color of skin were observed; the Doppler ultrasounds to vessels in lower extremities were examined, tests of coagulation and the PLT were tested before and after the operation. Finally, these data was managed statistically. Results: When examined by the Doppler ultrasound after the operation, 6 cases (15.0%) in the control group were found to have developed DVT; while the incidence in the experimental group was 1case (P＜0.05), this means it is statistically effective. And 3 cases in the control group were found to have light subcutaneous hemorrhage; while in the experimental group the subcutaneous hemorrhage incidence was 37 cases (92.5%), in which there were 30 cases with generalized subcutaneous hemorrhage. When 2 groups compared together, P＜0.05, it is statistically effective. Conclusions: It displays that combined Low Molecular Heparin and Intermittent Pneumatic Compression treatment can effectively prevent the morbidity of DVT in lower extremity, but it’s at the price of causing subcutaneous hemorrhage.

Key words: Low Molecular Heparin1, intermittent pneumatic compression （ IPC）2 , total kneearthroplasty（TKA）3, Subcutaneous hemorrhage4