Abstract: Abstract：Objective To evaluate the clinical features and Pathogenic Candida species in midtrimester-late pregnancy with vulvovaginal candidiasis. Methods A total of 294 pregnant out-patients in Tianjin Obstetrics & Gynecology Hospital were admissed between Jul 15th 2007 to Jan 30th 2008. Incidence surveys and routine laboratory examination were used. The Pathogenic Candida species were identified and the antifungal sensitivities in the Candida species were analyzed. Resulsts A total of 196 of 294 pregnancy women were involved in VVC with fungal culture, the morbidity is 66.67% (196/294). The mortidity with hanging drop method is 67.35%(132/196),the mortidity with smear method is 72.69%(143/196).No significant difference was found(p>0.05). Candida albicans was account for 95.41% (187/196),Non-albicans 4.59% (9/196).Candida albicans was observed in 131 cases by hanging drop method and in 137 cases by smear method, No significant difference was found(p>0.05). Non-candida albicans was observed in 1 cases by hanging drop method and in 6 cases by smear method.No significant difference was found(p=0.05). Drug-resistance was found in Candida albicans cases. 160 cases were resistant to tebinaifen. Non-albicans resistance against clotrimazole was 66.67% (6 / 9), and Candida albicans resistance to clotrimazole was 2.67% (5 / 187), the difference was significant ( p <0.01). Conclusion Candida albicans was still the most commonly identified species of pathogenic parasilosis yeasts. a higher detection rate of smear.different degrees resistance to commonly used antifungal drug were found in Candida albicans. resistance to clotrimazole in non-albicans was significantly higher than in Candida albicans.

Key words: pregnancy, vulvovaginitis, candida, drug-resisitance