Abstract: Abstract Objective: To investigate the related clinical-pathological factors of lymph node metastasis in patients with endometrial carcinoma. Methods: A retrospective analysis on 268 patients with endometrial carcinoma from Jan. 2002 to June. 2011 were selected.The patients were classified according to the WHO Classification of Tumors of uterine corpus (2003) and the latest FIGO stage criterion. The patients were divided into lymph node metastasis positive group and negtive. The differences of the following parameters between the two groups were compared: depth of myometrial invasion, pathological type, para-uterus invasion, differential degree of endometrioid carcinoma, age, the result of abdominal cytology and serum CA125 level. Simultaneously, the correlation between the above parameters and lymph node metastasis were analyzed. Result: The lymph node metastasis rate was 10.07%(27/268), and external iliac and obturator lymph nodes were the preferred sites which took up about 81.48%. The abdominal aorta lymph node metastasis rate was 9.68%(6/62). The metastasis rates of patients with deep myometrial invasion, non-endometrioid adenocarcinoma, middle and poorly differentiation, para-uterus invasion, abnormal serum CA125 level, age≥60 were significantly higher than those of patients with non or superficial myometrial invasion, endometrioid adenocarcinoma, well differentiation, without para-uterus invasion, normal serum CA125 level and age<60(P<0.01 for all), respectively. No significantly difference was observed between patients positive and negative for abdominal cytology detection. Differentiation degree of endometrioid adenocarcinoma, myometrial invasion and serum CA125 level are correlated with lymph node metastasis by logistic regression analysis. Conclusion: Deep myometrial invasion, middle & poorly differentiation and elevated serum CA125 level are high risk factors of lymph node metastasis in endometrial cancer patients.

Key words: endometrial neoplasms lymphatic metastasis lymphocytes, tumor-infiltrating CA-125 antigen risk factors pathology, clinical retrospective studies, 临床