Abstract: 【Abstract】 Objective: To investigate the effects to the patients’ blood coagulation function and the function of anemia cure as preoperative acute normovolemic hemodilution combined with intraoperative autologous blood recovery is used in elective surgery of brain. Methods: Comparing 16 selective neurosurgery patients’ APTT, PT, PLT, HB, HCT respectively at the time: before surgery, after normovolemic hemodilution, when the bleeding basically ended, intraoperative transfusion of autologous blood, and the preoperative collection of autologous blood. Results: after normovolemic hemodilution, as compared with preoperation, there were no significant changes in the patients’ PLT, APTT, PT, but the patients’ HB, HCT decreased significantly; when the bleeding basically ended, as compared with preoperation, the patients’ PLT, HB, HCT decreased significantly, and the patients’APTT, PT pronged; after intraoperative transfusion of autologous blood, as compared with those at the time when the bleeding basically ended, the patients’ APTT, PT pronged, the patients’ PLT further declined, but the patients’ HB, HCT increased significantly; after transfusion of the preoperatively collected autologous blood, as compared with those after the transfusion of intraoperative recovery autologous blood, the patients’ APTT, PT shorted significantly, the patients’ PLT ,HB, HCT increased significantly. Conclusions: In surgery with bleeding in larger amount, peoperative acute normovolemic hemodilution combined with intraoperative autologous blood recovery may help to correct the patients’ anemia. This method may also help to improve the patients’ coagulation function and surgical safety.

Key words: hemodilution blood coagulation hemorheology, intraoperative autologous blood recovery, craniocerebral operations