Abstract: Objective： The study was designed to determine the relationship between serum uric acid (UA) level and the presence and severity of coronary artery disease (CAD). Methods: A Total of 251 patients who underwent coronary angiography were included in this study according to the inclusion criteria. Patients were divided into CAD group and Non-CAD group according to the results of angiography. The severity of CAD was measured in terms of the number of vessels with disease. Results：1. The serum uric acid level was higher in CAD patients than that of Non-CAD patients (p＜0.001). Logistic regression analysis showed that the serum uric acid level was an independent risk factor of CAD (OR=1.007, 95%CI:1.002-1.011, p=0.004). 2. Although the serum uric acid level of one-, two-, three-vessel disease was higher than the non- vessel disease（p＜0.05）, among the three group there was no significant association. The same results were found in women, there was no significantly different. in men. 3. A significantly higher percentage of CAD patients was found in UA levels in the range of quartile 3 and 4 than that of UA levels of quartile 1 and 2 (p＜0.05). Conclusion: In conclusion, UA level was found to be associated with the presence but not with the severity of CAD. Particular attention should be paid with the UA level in clinical CAD diagnosis.

Key words: coronary artery disease, serum uric acid, coronary angiography, risk factors