Abstract: Objective To study change of LVH and eGFR in the process of therapy in the elderly patient with hypertension. Methods object of study were the elderly patients with hypertension hospitalized and the period of follow-up was five years or more than five years with comprehensive information including blood pressure, BMI, blood sugar, blood fat, blood creatinine, uric acid, urinary albumin/creatinine ratio, glomerular filtration rate, electrocardiogram and echocardiography . all patients would be divided into CKD group and NCKD group according to ACR and eGFR index. Candesartan was chosen mainly antihypertensive treatment measures to achieve the goal blood pressure during their hospitalization and the scheme was sustained during outpatient service.they were followed-up regularly.indexes related were compared at the same time points between groups, the same index were compared according to different followed-up time in the same group. Results (1) Compared between two groups, there were not statistically difference of corresponding systolic blood pressure and diastolic blood pressure, while there were statistically significance concerning difference of LVMI, LVH and eGFR at the same time point,(2) in comparison with the baseline state , except eGFR in NCKD group ,each index at various time point were improved with statistically significance ,including the systolic blood pressure, diastolic blood pressure, LVMI, LVH and eGFR, but the change with statistically significance did not appear among these indexes in the course of subsequent followed-up 4 years, there were not statistically difference concerning eGFR change in NCKD group in followed-up period of 5 years. Conclusion (1) The incidence of CKD and LVH were higher in the elderly hypertensive patients. (2) with blood pressure successful control, the LVH of patients was improved with glomerular filtration rate taken a turn for the better in CKD patients. The eGFR of patients with hypertension was a benign transformation process.