Abstract: Abstract Objective: To study the expression of IL-6, IL-17 and TGF-β in the tissue of cystitis glandularis(CG), investigate the role of nonresolving inflammation in the pathogenesis and development of CG. Methods: Collect 15 specimens of normal mucous membrane of bladder as control group (Group A)，43 specimens of curative cystitis glandularis as (Group B); 13 specimens of recurrent and cancerate cystitis glandularis as progression (Group C); Immunohistochemical (SABC) method was used to detect the expression of interleukin-6(IL-6), interleukin-17(IL-17) and TGF-β in the 3 groups. χ2 test was used to analyze the positive rates of the 3 factors in the 3 groups; Spearman rank correlation test was used to analyze the dependability of the 3 factors. Results: Positive rates of IL-6, IL-17, TGF-β in Group A、B、C: Group A were 20%（3/15）、13.3%（2/15）、33.3%（5/15）; Group B were 60.5%（26/43），62.8%（27/43），51.2%（22/43）; Group C were 92.3%（12/13），100%（13/13），100%（13/13）.There were significant differences between the 3 groups (χ2=15.824、23.036、14.274；P=0.003、0.000、0.006); there were no significant differences in expression levels of 3 groups between the different age and gender(P >0.05). Positive correlation exited between IL-6, IL-17,TGF-β and progression（r =0.728、0.785、0.659；P=0.000、0.000、0.000）；positive correlation existed between IL-17 and IL-6,TGF-β（r=0.997、0.761；P=0.000、0.000）. Conclusion: Positive expression of IL-6, IL-17, TGF-β and the synergetic effect of the 3 factors may play important roles in the pathogenesis and development of CG, further more nonresolving inflammation may play an important role in the pathogenesis and development of CG.

Key words: cystitis glandularis interleukins transforming growth factor, β type nonresolving inflammation immunohistochemistry