Abstract: Abstract Objective：To investigate the pathology diagnosis of the cases who were diagnosed as cervical erosion by naked eyes and the expression of human papillomavirus type 16/18 E6 protein and it’s clinical significance. Methods:Choose the age of 18-65 cervical minor erosion group (30 cases)、moderate erosion group(41 cases)、serious erosion group(29 cases),smooth group 100 cases(the contrast group).Clearring those cases’ pathology organization diagnose. The expression of human papillomavirus type 16/18 E6 protein was detected by immunohistochemistry. Results: （1）The pathology organization diagnose result of every group are：normal、cervical inflammation、CINI、CINII、CINIII and cervical cancer.The constituent ratios of cervical intraepithelial neoplasia and cervical cancer in the three groups were becoming higher and higher, the differences of consitituent ratios were statistically significant（P<0.05）. The erosion group compare with the smooth group（P<0.001）.（2）The expression of HPV16/18 E6 among the erosion groups is higher than smooth group, the differences were statistically significant（P<0.05）。Compare serious and moderate，serious and minor ,both were statistically significant（P<0.05）．Among moderate and minor, the differences were not statistically significant（P>0.05）．Conclusion: In the naked eyes imagined cervical erosion cases,their organization diagnose are diversity,more higher it’s erosion,the possibility of developing into CIN or cervical cancer is more greater,the expression level of HPV16/18 E6 is more higher.

Key words: cervical erosion, cervical intraepithelial neoplasia（CIN）, cervical cancer, human papillomavirus16/18 type, E6 protein