Abstract: To investigate the intervention effect on Tumor Immune Escape by BuFeiXiaoJiYin combined Chemotherapy on middle and advanced stage of non-small cell lung cancer(NSCLC) with the Yin and Qin deficiency type. Methods: 48 cases of middle and advanced stage of non-small cell lung cancer with the Yin and Qin deficiency type were randomly divided into the treatment group (BuFeiXiaoJiYin + chemotherapy) and the control group (chemotherapy alone), every 4 weeks for a cycle, clinical symptoms, immune suppression cell and follow-up forward curative effect were observed after the two cycles. Results: The clinical symptoms of the two groups were alleviated due to treatment (P < 0.01), and the treatment group showed better than the control group（P<0.05）. The immune suppression cells of the treatment group dropped after the two cycles（P<0.01）, however, the cells grew up at the control group（P<0.05）.The immune suppression cells in the treatment group dropped obviously , compared with the control group after treatment , and there was significant difference between the two groups(P < 0.01). The median survival and the disease progressing time of the two groups was 310 d and 226, 139 d and 100 d respectively by the follow-up, 1 year accumulative total survival rates were 44% and 30.4%, the data of the treatment group are all better than the control group, while there was not statistical differences (P﹥0.05).Conclusion: BuFeiXiaoJiYin combined chemotherapy could suppress the immune suppression cell secretion and intervene tumor immune escape, Integrating modern and traditional medicine was superior to chemotherapy alone at alleviating symptoms and prolonging survival period and disease free time .