Abstract: Objective:To observe the expression of VEGF in the endometrial-myometrial interface of adenomyosis.Methods:Immunohistochemistry SP method was adopted to determine the expression of VEGF in EMI of twenty cases of adenomyosis and of twenty cases of control subjects.Results:In adenomyosis group the expression level of VEGF was higher in EMI versus outer layer in the whole menstrual cycle (p<0.05).Between the groups, the expression level of VEGF was higher in EMI of adenomyosis group than that of control group in the whole menstrual cycle(p<0.05).Conclusion:The higher expression of VEGF in EMI is closely related to the pathogenesis of adenomyosis possibly.