Abstract:

[Abstract] Objective  To investigate the calcium cavity protein (CALU, rs2290228) genotype distribution in Chinese Han population and the correlation between CALU（rs2290228）polymorphism and the stable dose of warfarin in patients with aortic valve replacement. Methods  All of 226 cases were detected by Snapshot technology to explore the genotype and allele frequencies. The correlation between gene polymorphism and the stable dose of warfarin was compared in 176 patients after valve replacement, and which was also compared between 176 patients and 50 controls.Results  In total of 226 cases, the number of TT, CT and CC genotypes were 2 (0.9%), 88(38.9%) and 136 (60.2%),with the frequencies of 0.9%, 38.9% and 60.2% respectively. The frequencies of T allele and C allele were 20.4% and 79.6%. The stable maintenance doses of warfarin in patients with TT，CT and CC were (2.75±0.35) mg/d, (3.37±0.81) mg/d and (3.14±0.89) mg/d. There were no significant differences in the stable maintenance dosage of warfarin, prothrombin time (PT) and INR value between three genotype groups (P > 0.05). Conclusion  The CALU（rs2290228）polymorphism in Chinese Han population may not be an influencing factor in the individual warfarin maintenance dosage in patients with aortic valve replacement.

Key words: CALU, gene polymorphism, warfarin, valve replacement surgery