Abstract: Objective To observe the efficacy and safety of calcipotriol in the treatment of palmoplantar pustulosis . Methods 80 patients with palmoplantar pustulosis were divided into two groups randomly: 40 patients were treaded with triamcinolone twice a day for 8 weeks , 40 patients were treaded with calcipotriol twice a day for 8 weeks respectively .After 2 、4 and 8 weeks , all the patients are required regular return visit . We observe the area 、erythema 、scale 、 the number and area of the pustule 、the alteration 、the side effects ，etc , and analyse the recovery rate 、 the effective rate and the recurrence rate with the method of the statistics. Results After 8 weeksˊ treatment , the provement of the plaque by using calcipotriol was more higher than triamcinolone (P<0.05) ，and in the follow-up visit the recurrence rate was inferior (P<0.05). Conclusion Calcipotriol were safe and effective in therapy for palmoplantar pustulosis ,and the recurrence rate is low .

Key words: calcipotriol, palmoplantarpustulosis, theefficacy