Abstract: Objective: To explore the relationships between H.pylori infection and the functional dyspepsia through gastric electrical activity tested by 4-lead Electrogastrography (EGG) , and the effect on functional dyspepsia with eradication of Hp. Methods: To measure and analyze the data of the gastric electrical activity of 163 children with FD (103 children with HP infection, 60 without HP infection and 84 with HP infection negative after therapy) and 22 healthy controls by 4-lead EGG. Results: Infection group is compared with the non-infection group, under different slow wave frequency tests, more obvious in the percentage difference of the postprandial than that of pre-prandial. No difference was found in DF、DP、DFIC and DPIC under two conditions. Infection group is compared with the eradication group, under different slow wave frequency tests, no difference was found in the percentage difference between postprandial and pre-prandial. However, the data different of DF、DP、DFIC and DPIC between the pre-prandial and postprandial is more clear. Conclusions: The severity degree of the symptoms in children’s functional dyspepsia is closely related with H.pylori infection, the eradication improves the gastric electrical activity and reliefs the postprandial symptom of children with functional dyspepsia under H.pylori infection.

Key words: H.pylori, 4-lead Electrogastrography (EGG), functional dyspepsia