Abstract:

[Abstract] Objective  To investigate the correlation of endothelial function variation with pulse pressure index in Uygur acute coronary syndrome patients in Xinjiang. Methods  Uygur patients were divided into acute coronary syndrome group (n=208) and control group (n=157) according to their Coronary angiography results. Height, weight and blood pressure were measured on admission and basic medical history were recorded. Fasting blood glucose (FBG), three acyl glycerin (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL - C), low density lipoprotein cholesterol (LDL - C) were examined using fasting venous blood; Plasma Coagulation Factor Ⅷ (CFⅧ) and von Willebrand factor（vWF）were examined using ELISA. Results  There are no statistical difference in age, gender, history of hypertension, diabetes history, history of smoking, drinking, body mass index, PPI, HDL - C and FBG between two groups. The systolic pressure, diastolic blood pressure, pulse pressure, TG, TC, LDL - C and vWF, CF Ⅷ levels in acute coronary syndrome group were higher than those in the control group (all P < 0.05). The levels of plasma vWF and CFⅧ were positively correlated with pulse pressure and PPI, it also was positively correlated between the levels of plasma vWF and CFⅧ (P < 0.01). Conclusion  The endothelial function was significantly impaired in Xinjiang Uygur patients with acute coronary syndromes, and vascular endothelial damage was positively correlated with pulse pressure and PPI. The pulse pressure and PPI can be used to evaluate the vascular endothelial function indirectly.

Key words: Acute coronary syndromes, pulse pressure index, endothelial function, Uygur race, vWF