Abstract:

[Abstract]   Objective   To study the clinical distribution and detection of the efflux pump gene in multiple drug-re?
sistant acinetobacter baumannii.   Methods   The clinical distribution of 96 strains of multiple drug-resistant acinetobacter baumannii was analyzed. K-B method was used to detect 96 strains of multi resistant bauman resisted to 15 kinds of antibiotics. PCR amplification was used to detect the efflux pump gene.   Results   Ninety-six strains of multiple drug-resistant acinetobacter baumannii mainly distributed in intensive care unit (ICU, 54.2%) and respiratory department (18.8%). The drug resistance rates to quinolone, cephalosporins, amino glucoside, tetracycline were above 70%. The 52 strains of multiple drug -resistant acinetobacter baumannii detected in ICU included 18 strains of adeB (34.62%), 16 strains of adeR (30.77%),18 strains of adeS (34.62%), 18 strains of adeJ (34.62%), 0 strain of adeE and18 strains of adeM (34.62%). The18 strains of multiple drug-resistant acinetobacter baumannii detected in respiratory department included 9 strains of adeB, 8 strains of adeR, 8 strains of adeS, 8 strains of adeJ, 0 strain of adeE and 8 strains of adeM.   Conclusion   Efflux pump genes are important factors for multiple drug-resistant acinetobacter baumannii distributed in ICU and respiratory department.

Key words: acinetobacter baumannii, microbial sensitivity tests, multiple drug resistant, efflux pump gene