Abstract: Abstract: Objective To investigate the risk factors of dual anti-platelet treatment related upper gastrointestinal hemorrhage. Methods 2004 patients taking dual anti-platelet treatment for coronary heart disease were retrospectively analyzed and followed up. Results The incidence of dual anti-platelet treatment related upper gastrointestinal bleeding was associated with age, smoke, history of hypertension , abnormal test parameters and the use of PPI protective acid-suppressing agents. Conclusion The long term use of dual anti-platelet treatment can increase the risk upper gastrointestinal bleeding in the elderly patients, in addition to smoke, history of hypertension , abnormal test parameters. Gastric mucosal protective or acid suppressing agents is effective in reducing the occurrence of upper gastrointestinal bleeding.

Key words: Dual anti-platelet treatment, Upper gastrointestinal bleeding, Risk factor