Abstract: 【Abstract】　Objective　To investigate the effect and safety of intensive insulin therapy on critically trauma patients who had stress hyperglycemia, with different level goal blood glucose in surgery intensive care unit(SICU).Methods We prospectively analyzed SICU patients in 2010.1-2012.7 , whose admission blood glucose and 30 minutes blood glucose were both over 11．1mmol／L ，but without history of diabetes．Of total 153 patients were classified according to their goal blood glucose for three groups：intensive insulin therapy (IIT)group，4.0一6.1mmol/L ；NICE SUGAR(NST)group , 6．2-8．3 mmol／L, cantract insulin therapy （CIT）group was 9.9-11.1mmol/ L; each group had 51 patients. To collecting datas of three groups patients on the，the insulin doses each day, rate of hypoglycemia, final blood glucose,APACHEII scores ,time of the ventilatory support, the days of stay in ICU ,morbidity and mortality rate . Results In three groups patients, time of the ventilatory support, the days of stay in ICU ,morbidity were significantly lower in NST group than CIT group, （P

Key words: critically trauma, surgery intensive care unit, stress hyperglycemia, intensive insulin therapy