Abstract: Objective： To investigate the value of model for end -stage liver disease (MELD) score, MELD with incorporation of serum sodium (MELD-Na) score and integrated MELD (iMELD) score for evaluation of prognosis of chronic liver failure. Methods ：A total of 159 consecutive patients with chronic liver failure were included in the study and divided into two groups (death group and survival group) according to the prognosis. The levels of total bilirubin (TBIL), serum creatinine (Cr), prothrombin time (PT), PT international normalized ratio (INR), Serum sodium (Na), age, MELD, MELD-Na and iMELD were calculated respectively and the comparative analysis was performed. Areas under the receiver operating characteristic curve (AUC-ROC) of MELD, MELD-Na and iMELD were used to assess the prognosis in patients with chronic liver failure. Results: The values of TBIL, INR, MELD, MELD-Na and iMELD were significantly higher in death group than those in survival group (P < 0.01). The serum level of Na+ was significantly lower in death group than that of survival group (P < 0.01). The mortality of liver failure was higher in patients with the increased scores of MELD, MELD-Na and iMELD. The area under curve (AUC) values generated by the ROC curves was no difference respectively (P > 0.05) for MELD score (AUC=0.691), MELD-Na score (AUC=0.690) and iMELD score (AUC=0.674) . The cut-off scores of three systems were 25.8 (MELD), 31.0 (MELD-Na) and 53.5 (iMELD) respectively, which could discriminate higher and lower mortality accurately. Conclusion: MELD, MELD-Na and iMELD score can predict liver failure patients undergoing artificial liver comprehensive medical treatment combined short-term clinical outcomes.

Key words: Liver failure, model of end-stage liver disease, MELD-Na model assessment of liver failure, prognosis